Male penile impotence has been around even during the earliest civilizations. This male sexual condition can be considered as an embarrassing one because any man that has it is unable to successfully perform sexual intercourse. For any successful sexual intercourse, it is required that a man has a fully erect penis so vaginal penetration is possible. Without an erection, the penis will not be able to enter inside the vagina, regardless of how forceful they try.
Over a decade ago, the pharmaceutical giant, Pfizer, released an ED treatment medication called Viagra that forever revolutionized the treatment of male sexual impotence. The mechanism of action of the drug was very effective that it revolutionized a way into the discovery of other ED medications using other active ingredients aside from that used in making V-a. These new ED drugs include avanafil, vardenafil, and tadalafil. All four use different active ingredients to achieve the same effect or mechanism of action – the relaxing of the smooth muscle lining the penis to allow blood to be pumped inside the cavities within the penis. Continue reading